@thenexusofprivacy I am totally blind and use both NVDA and Talkback. I am not a Mastodon user, but I am on Friendica, which is compatible. Tweesecake is 100% accessible and was designed for the blind. It is a Windows program. Pachli and Tusky for Android are also accessible. I believe Pachli is based on Tusky, but with a focus on accessibility. I may be wrong on the second part. As someone who uses my phone with an external keyboard, I do find it annoying that I must use the touchscreen in Pachli to edit posts, and that it takes several steps to do it. Plus, there is no easy keyboard shortcut to go from the top to the bottom of a list, so that, if I am viewing old posts, I have to go through all of them to reach the top. Enafore is related to Semaphore. I believe it's the version that is now being updated. However, while I have heard it claimed that it is accessible, I have no idea how to edit my posts (a feature it has which Semaphore doesn't). Furthermore, When I hit "reply", a dialogue opens, but there is no edit box, and half of the time, when I go to the site, I don't see the edit box in which I'm supposed to write my post.

As it stands now, my suggestion would be to use Tweesecake for Windows (100% accessible, but only for 64-bit versions), and Pachli for Android (with the knowledge that it can be frustrating to use with a keyboard). Semaphore is good as a web-based client, but without the ability to edit posts. The two things I would like to see in a new client are 32-bit support for Windows (including older versions), and a feature that I can't seem to find anywhere. Namely, the ability to view posts with their comments, instead of having them scattered everywhere. If I see five separate posts, I want to click on them individually to read their respective comments, not see twenty comments from all five posts all over the place.